The History and Science Behind Custom Enzyme Manufacturing: From Discovery to Production

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Amano Enzyme  was founded over 120 years ago in Japan as a pharmaceutical business and expanded into enzyme production in 1948.  Enzymes are proteins that act as catalysts and speed up chemical reactions that are essential to life and are found in all living organisms. Enzymes have been used for centuries in food production and other applications, yet it was not until the early 20th century that scientists began to truly understand how enzymes work.

James Sumner achieved a groundbreaking milestone in 1926 by successfully crystallizing the enzyme urease, marking a pivotal moment in enzyme research. This accomplishment demonstrated that enzymes could be purified and subjected to more systematic study. Since Sumner’s pioneering work, the field of enzyme science has made substantial advancements. We have come to understand that enzymes are proteins that function by selectively binding to particular molecules and facilitating their reactions. Presently, the utilization of enzymes through advanced technology continues to be a fundamental aspect and guiding principle of biotechnology, contributing to the betterment of human existence.

Custom Enzyme Manufacturing

The development of custom enzymes is a relatively new field. The first custom enzymes were created in the 1970s, with the field seeing rapid growth in recent years. Amano Enzyme is the world’s #1 manufacturer of custom enzymes. Amano enzymes are used in a wide range of industries, including food, pharmaceuticals, and environmental remediation.

Custom enzymes are designed to have specific properties, such as increased activity or specificity, which makes them ideal for a wide range of applications.

The Production Process Behind Custom Enzyme Manufacturing

When you need a new concept, new flavor, have a formulation issue and more, chances are Amano Enzyme can service your needs in a timely and effective manner. At Amano Enzyme, the custom enzyme manufacturing   process begins with the identification of a need. We work with each individual customer to identify the specific properties that they are looking for in an enzyme. Once the desired properties have been identified, we use our expertise in enzyme science to design and develop a custom enzyme.

The  custom enzyme manufacturing process is complex and requires a high level of expertise. At Amano Enzyme we have a team of experienced scientists and engineers and pride ourselves on producing high-quality enzymes and offering our client’s a reliable supply.

The process of manufacturing custom enzymes can be categorized into three primary stages:

  1. Enzyme design: The initial step involves determining the desired characteristics of the custom enzyme. At Amano Enzyme, our expertise in enzyme science enables us to design enzymes that possess the desired properties.
  2. Enzyme production: After the custom enzyme has been designed, it must be produced. Amano Enzyme employs various techniques for custom enzyme production, including fermentation, chemical synthesis, and recombinant DNA technology.
  3. Enzyme purification: Once the custom enzyme has been manufactured, it undergoes purification. This crucial step ensures the enzyme’s freedom from impurities and verifies its desired activity. Amano Enzyme utilizes diverse methods, such as chromatography, electrophoresis, and precipitation, to purify custom enzymes.

Custom Enzymes are a Powerful Tool

At Amano Enzyme we manufacture  custom enzymes which can be used to improve a wide range of products and processes. As a leader in the field of custom enzyme manufacturing, Amano Enzyme is committed to helping our customers create innovative and sustainable products.  

Utilizing custom enzymes offers several advantages, including:

  1. Enhanced efficiency: Custom enzymes can be specifically designed to exhibit greater efficiency compared to natural enzymes. This characteristic contributes to heightened productivity and cost reduction.
  2. Enhanced product quality: Custom enzymes can be tailored to enhance the quality of various products. For instance, they can be employed to extend the shelf life of food or enhance the flavor profiles of beverages.
  3. Decreased environmental footprint: Custom enzymes provide an opportunity to replace harmful chemicals in certain applications. For instance, they can be utilized to effectively clean up oil spills or treat wastewater, leading to a reduced environmental impact.

Custom Enzyme Quality Assurance

At Amano Enzyme we have a rigorous quality assurance program in place that ensures that all of our products meet or exceed customer expectations.

The quality assurance program at Amano Enzyme begins with the selection of raw materials. We use the highest quality raw materials from trusted suppliers. Once the raw materials are received, they are carefully inspected and tested to ensure that they meet Amano’s strict quality standards.

The manufacturing process at Amano Enzyme is also highly controlled. We rely on state-of-the-art equipment and processes to ensure that our products are produced to the highest standards. All products are tested at multiple stages of the manufacturing process to ensure that they meet our high quality standards.

Once a product is manufactured, it is carefully packaged and stored to ensure that it remains in good condition until it is shipped to the customer. At Amano Enzyme we also offer a variety of quality assurance services to our customers, including product testing, quality audits, and training.

Amano enzymes can improve the functionality, flavor, and overall quality of products, making them better for both people and the planet. Work with us to improve your products and create custom enzyme technology to make a positive impact on the world.


Our dedicated professional team is here to answer your questions and provide support. We also offer samples of enzyme products. Feel free to contact us.